Imaging Gallery

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Holiday Party 2022.
AHA 2022.
AHA 2022.
Cathedral of Learning.
Discussion in the conference room.
Acoustic field calibration.
Multi-modality biomedical ultrasound imaging.
Microbubble fabrication.
Rabbit femoral artery sections before (upper panels) and 6 weeks after (middle and lower panels) balloon injury.
Contrast ultrasound of the rabbit femoral arteries before (A, B) and 6 weeks after (C, D) balloon injury.
Ultrasound radiation force-mediated delivery of stem cells to vascular targets.
The MSCs adherent to the aortic endoluminal surface after ultrasound mediated delivery survive and undergo morphological changes.
Postmortem histology of tumors in mice after intravenous delivery of pCMV-TK (a, c, d) or pEGFP-C1 (b)-loaded microbubbles and treatment with ultrasound and ganciclovir. (a, b).
Growth of murine tumors after intravenous injection of either pCMV-TK (□) or pEGFP-C1 (▲)-loaded microbubbles and treated with ultrasound.
In vitro model of microvascular embolization and sonoreperfusion.
Quantification of sonothrombolysis effects. Blood clot volume derivation from an optical coherence tomography (OCT) scan and 3-D rendering of thrombus.
Quantification of microbubble attachment of mesenchymal stem cells (MSCs) using flow cytometry.
Acoustic radiation force on microbubbles can be used to delivery stem cells for vascular cell therapy.
3D tumor volumes in mice receiving UTMD-mediated delivery of control siRNA (top) or UTMD-mediated delivery of EGFR–siRNA (bottom).
The UPMC Cam, the ultra-fast imaging system for studyng the dyanmic behavior of microbubbles.
Overview of the UPMC Cam. This system is capable of imaging microscopic bright-field and fluorescence movies at 25 million frames per second for 128 frames.
Optical design of the UPMC Cam.
Sequential frames of a bright-field movie of lipid microbubbles under ultrasound excitation (f= 2.25 MHz, Pa = 1.0 MPa), demonstrating ultrasound induced microbubble vibration and breaking.
Sequential bright-field high-speed microscopic images of a microbubble adjacent to a thrombus during ultrasound delivery (1 MHz, 1.5 MPa).
Sequential bright-field high-speed microscopic images of multiple microbubbles (arrowheads in frame 7) adjacent to a thrombus (arrow in frame 7) during ultrasound exposure.
The dual-mode US system for US-TS Imaging.
Contrast enhanced ultrasound imaging using microbubbles targeted to E-selectin can be used for ischemic memory imaging.
Immunofluorescent staining of post-ischemic (A-C) and nonischemic (D-F) myocardium 4 hours after reperfusion.
Nonlinear intravascular ultrasound imaging with microbubble based contrast agents.
In vivo model of sonoreperfusion. Contrast ultrasound images from control (top) and treatment (bottom) animals at each of four experimental stages.
Hematoxylin and eosin-stained treated (c,d) and control(a,b) rat hindlimb muscle. The rats that received treatment had less microvascular obstruction than controls.
High-speed fluorescence recordings with the UPMC Cam reveal a variety of microbubble coating behaviors not evident from bright-field recordings.
High-speed fluorescence recordings with the UPMC Cam reveal a variety of microbubble coating behaviors not evident from bright-field recordings.

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