Faculty & Staff

Post Doctoral Fellows

Brandon Helfield, PhD

Post-doctoral Fellow, University Pittsburgh UPMC Heart and Vascular Institute




Peer Reviewed Articles

1. Helfield BL, Cherin E, Foster S, Goertz DE. Investigating the subharmonic response of individual phospholipid encapsulated microbubbles at high frequencies: a comparative study of five agents. Ultrasound Med Biol 2012;38:846-863.

2. Helfield BL, Huo X, Williams R, Goertz DE. The effect of preactivation vial temperature on the acoustic properties of Definity. Ultrasound Med Biol 2012;38:1298–1305.

3. Huynh E, Lovell JF, Helfield BL, Jeon M, Kim C, Goertz DE, Wilson BC, Zheng G. Porphyrin shell microbubbles with intrinsic ultrasound and photoacoustic properties. J Am Chem Soc 2012;134:16464–16467.

4. Helfield BL, Cherin E, Foster FS, Goertz DE. The effect of binding on the subharmonic emissions from individual lipid-encapsulated microbubbles at transmit frequencies of 11 and 25 MHz. Ultrasound Med Biol 2013;39:345–359.

5. Helfield BL, Goertz DE. Nonlinear resonance behavior and linear shell estimates for DefinityTM and MicroMarkerTM assessed with acoustic microbubble spectroscopy. J Acoust Soc Am 2013;133:1158–68.

6. Jeon M, Song W, Huynh E, Kim J, Kim J, Helfield BL, Leung BYC, Goertz DE, Zheng G, Oh J, Lovell J, Kim C.  Methylene blue microbubbles as a model dual-modality contrast agent for ultrasound and activatable photoacoustic imaging, J Biomed Optics 2014;19:016005.

7. Helfield BL, Leung BYC, Huo X, Goertz DE. Scaling of the viscoelastic shell properties of phospholipid encapsulated microbubbles with ultrasound frequency. Ultrasonics 2014;6:1419-1424.

8. Helfield BL, Leung BYC, Goertz DE. The effect of boundary proximity on the response of individual ultrasound contrast agent microbubbles. Phys Med Biol 2014;59:1721–1745.

9. Helfield BL, Leung BYC, Goertz DE. The influence of compliant boundary proximity on the fundamental and subharmonic emissions from individual microbubbles. J Acoust Soc Am Express Letters 2014;136:EL40-EL46.

10.  Huynh E, Leung BYC, Helfield BL, Shakiba M, Gandier J, Jin CS, Master ER, Wilson BC, Goertz DE, Zheng G. In situ conversion of porphyrin microbubbles to nanoparticles for multimodality imaging. Nature Nanotechnology 2015;10:325-332.

11. Helfield B, Black JJ, Qin B, Pacella J, Chen X, Villanueva FS. Fluid viscosity affects the fragmentation and inertial cavitation threshold of lipid encapsulated microbubbles. Ultrasound Med Biol 2016;42(3):782-794. EPub 2015 December 07. PMID: 26674676.

12. Helfield B, Chen X, Qin B, Villanueva FS. Individual lipid encapsulated microbubble radial oscillations: Effects of fluid viscosity. J Acoust Soc Am 2016;139(1):204-214. Epub 2016 January 11. PMID: 26827018.

13. Helfield B, Chen X, Watkins S, Villanueva FS. Biophysical insight into mechanisms of sonoporation. PNAS 2016; 113(36):9983-9988. EPub 2016 August 22. doi: 10.1073/pnas.1606915113. PMID: 27551081.

14. Helfield B, Chen X, Qin B, Watkins SC, Villanueva FS.  Mechanistic insight into sonoporation with ultrasound-stimulated polymer microbubbles. Ultrasound Med Biol 2017; (In press). Epub 2017 Aug 25. doi: 10.1016/j.ultrasmedbio.2017.07.017.