Research Projects
New Imaging Strategies
- Angiogenesis imaging
- Ischemic memory imaging
- Detection and molecular characterization of vulnerable atherosclerotic plaque
- Stem cell tracking
- Molecular imaging and quantification of pancreatic islet cell mass
- Cardiac electrophysiology mapping using contrast agents – NIH Pioneer Award
- Nonlinear IVUS
- Other ultrasound-based molecular imaging strategies not utilizing microbubbles
Novel Ultrasound Contrast Agents
- Development of polymer microbubbles
- Optimization of microbubble adhesion properties using computational modeling of adhesive dynamics
Microbubble Dynamics
- Dynamic microbubble behavior using ultra-high speed microscopy
- Mechanisms of action for ultrasound-microbubble-mediated therapy
New Clinical Therapeutic Applications
- Ultrasound-microbubble-mediated gene delivery via ultrasound induced microbubble destruction
- Ultrasound-microbubble-mediated drug delivery
- Therapeutic application of acoustic radiation force to facilitate endothelial cell trafficking
- Ultrasound-microbubble-mediated microvascular reperfusion