Faculty & Staff
Muhammad Wahab Amjad, PhD
Visiting Scholar, University of Pittsburgh School of Medicine (Cardiology)
UPMC Heart and Vascular Institute
Peer Reviewed Articles
1. Amin MCIM, Albawani SM and Amjad MW. A Comparative Study of the Compaction Properties of Binary and Bilayer Tablets of Direct Compression Excipients. Trop J Pharm Res 2012;3(4):585-594. DOI: 10.4314/tjpr.v11i4.9.
2. Bukhari SNA, Ahmad W, Butt AM, Ahmad N, Amjad MW, Hussain MA, Shah VH, Trivedi AR. Synthesis and evaluation of chalcone analogues and pyrimidines as cyclooxygenase (COX) inhibitors. Afr J Pharm Pharmacol 2012;6(14):1064-1068. DOI:10.5897/AJPP12.022.
3. Amjad MW, Amin MCIM, Katas H, Butt AM. Doxorubicin-loaded cholic acid-polyethyleneimine micelles for targeted delivery of antitumor drugs: synthesis, characterization, and evaluation of their in vitro cytotoxicity. Nanoscale Res Lett 2012;7(1):687. DOI: 10.1186/1556-276X-7-687.
4. SN Bukhari, AM Butt, MW Amjad, W Ahmad, VH Shah, AR Trivedi. Synthesis and evaluation of chalcone analogues-based pyrimidines as angiotensin converting enzyme inhibitors. Pak J Biol Sci 2013;16(21):1368-1372. DOI: 10.3923/pjbs.2013.1368.1372.
5. Bukhari SNA, Jantan IB, Jasamai M, Ahmad W, Amjad MW. Synthesis and Biological Evaluation of Curcumin Analogues. J Med Sci 2013;13(7):501-513. DOI: 10.3923/jms.2013.501.513.
6. Bukhari SNA, Jantan I, Masand VH, Mahajan DT, Sher M, Naeem-ul-Hassan M, Amjad MW. Synthesis of a, b-unsaturated carbonylbased compounds as acetylcholinesterase and butyrylcholinesterase inhibitors: Characterization, molecular modeling, QSAR studies and effect against amyloid b-induced cytotoxicity. Eur J Med Chem 2014;83:355-365. DOI: 10.1016/j.ejmech.2014.06.034.
7. Bukhari SNA , Lauro G, Jantan I, Bifulco G, Amjad MW. Pharmacological evaluation and docking studies of a,b-unsaturated carbonyl based synthetic compounds as inhibitors of secretory phospholipase A2, cyclooxygenases, lipoxygenase and proinflammatory cytokines. Bioorg Med Chem 2014;22(15):4151-4161. https://doi.org/10.1016/j.bmc.2014.05.052.
8. Amjad MW, Amin MCIM, Mahali SM, Katas H, Ismail I, Hassan MNU, Chuang VTG. Nanoscale Diblock Copolymer Micelles: Characterizations and Estimation of the Effective Diffusion Coefficients of Biomolecules Release through Cylindrical Diffusion Model. Plos One 2014;9(8);e105234. DOI: 10.1371/journal.pone.0105234.
9. Bukhari SN, Zhang X, Jantan I, Zhu HL, Amjad MW, Masand VH. Synthesis, Molecular Modeling, and Biological Evaluation of Novel 1, 3-Diphenyl-2-propen-1-one Based Pyrazolines as Anti-inflammatory Agents. Chem Biol Drug Des 2015;85(6):729-742. DOI: 10.1111/cbdd.12457.
10. Amjad MW, Amin MCIM, Katas H, Butt AM, Kesharwani P, and Iyer AK. In Vivo Antitumor Activity of Folate-Conjugated Cholic Acid-Polyethylenimine Micelles for the Codelivery of Doxorubicin and siRNA to Colorectal Adenocarcinomas. Mol Pharm 2015;12(12):4247-4258. DOI: 10.1021/acs.molpharmaceut.5b00827.
11. Bukhari SNA, Lauro G, Jantan I, Chee CF, Amjad MW, Bifulco G, Sher H, Abdullah I & Rahman NA. Anti-inflammatory trends of new benzimidazole derivatives. Future Med Chem 2016;8(16):1953-1967. DOI: 10.4155/fmc-2016-0062.
12. Leng J, Qin HL, Zhu K, Jantan I, Hussain MA, Sher M, Amjad MW, Naeem-Ul-Hassan M, Ahmad W, Bukhari SN. Evaluation of multifunctional synthetic tetralone derivatives for treatment of Alzheimer's disease. Chem Biol Drug Des 2016;88(6):889-898. DOI: 10.1111/cbdd.12822.
13. Zha GF, Zhang CP, Qin HL, Jantan I, Sher M, Amjad MW, Hussain MA, Hussain Z, Bukhari SN. Biological evaluation of synthetic α,β-unsaturated carbonyl based cyclohexanone derivatives as neuroprotective novel inhibitors of acetylcholinesterase, butyrylcholinesterase and amyloid-β aggregation. Bioorg Med Chem 2016;24(10):2352-2359. DOI: 10.1016/j.bmc.2016.04.015.
14. Ng KE, Amin MCIM, Katas H, Amjad MW, Butt AM, Kesharwani P, Iyer AK. pH-Responsive Triblock Copolymeric Micelles Decorated with a Cell-Penetrating Peptide Provide Efficient Doxorubicin Delivery. Nanoscale Res Lett 2016;11(1):539. DOI: 10.1186/s11671-016-1755-4.
15. Qin HL, Leng J, Zhang CP, Jantan I, Amjad MW, Sher M, Naeem-Ul-Hassan M, Hussain MA, Bukhari SN. Synthesis of α,β-Unsaturated Carbonyl-Based Compounds, Oxime and Oxime Ether Analogs as Potential Anticancer Agents for Overcoming Cancer Multidrug Resistance by Modulation of Efflux Pumps in Tumor Cells. J Med Chem 2016;59(7):3549-3561. DOI: 10.1021/acs.jmedchem.6b00276.
16. Qin HL, Leng J, Youssif BGM, Amjad MW, Raja MAG, Hussain MA, Hussain Z, Kazmi SN, Bukhari SNA. Synthesis and mechanistic studies of curcumin analog-based oximes as potential anticancer agents. Chem Biol Drug Des 2017;90(3):443-449. DOI: 10.1111/cbdd.12964.
17. Zha GF, Qin HL, Youssif BGM, Amjad MW, Raja MAG, Abdelazeem AH, Bukhari SNA. Discovery of potential anticancer multi-targeted ligustrazine based cyclohexanone and oxime analogs overcoming the cancer multidrug resistance. Eur J Med Chem 2017;135:34-48. DOI: 10.1016/j.ejmech.2017.04.025.
18. Aluwi MFFM, Rullah K, Haque MA, Yamin BM, Ahmad W, Amjad MW, Leong SW, Fahmizar NA, Jalil J, Abas F, Ismail NH, Jantan I, Lam KW. Suppression of PGE2 production via disruption of MAPK phosphorylation by unsymmetrical dicarbonyl curcumin derivatives. Med Chem Res 2017;26:3323–3335. DOI: 10.1007/s00044-017-2025-4.
19. Zaman M, Khalid U, Raja MAG, Siddique W, Sultana K, Amjad MW, Rehman AU & Khan MA. Fabrication and Characterization of Matrix-Type Transdermal Patches Loaded with Ramipril and Repaglinide Through Cellulose-based Hydrophilic and Hydrophobic Polymers: In Vitro and Ex Vivo Permeation Studies. Polym Plast Technol Mater 2017;56(16):1713-1722. DOI: 10.1080/03602559.2017.1289400.
20. Raja MAG, Amjad MW, Alshammari HO. Preparation and in vitro characterizations of VEGF siRNA-loaded Chitosan- Poly-D-glutamic acid sodium salt nanoparticles. Int J Pharm Phytopharmacological Res 2018;8(6):92-97. https://eijppr.com/0I58kF9.
21. Amjad MW, Raja MAG, Hassan KAM. Development and characterization of dicer substrate siRNA-loaded cholic acid-polyethylenimine micelles for gene silencing in the treatment of cancer. Pharmacophore 2018;9(4):36-40. https://pharmacophorejournal.com/Kh3C4pQ.
22. Zaman M, Hanif M, Amjad MW, Murtaza H, Raja MAG, Kashif M. Development and validation of rp-hplc method for simultaneous estimation of tizanidine hcl and meloxicam in bilayer mucoadhesive buccal films. Acta Pol Pharm 2018;75(4):851-859. DOI: 10.32383/appdr/80742.
23. Raja MAG, Amjad MW, Hassan KAM. Comparative Evaluation of siRNA-loaded Chitosan Tripolyphosphate/Dextran Sulfate Nanoparticles Prepared by Adsorption Method: In Vitro Characterizations. Int J Pharm Phytopharmacological Res 2018;8(5):1-6. https://eijppr.com/jjghzry.
24. Wang M, Qin HL, Leng J, Ameeduzzafar, Amjad MW, Raja MAG, Hussain MA, Bukhari SNA. Synthesis and biological evaluation of new tetramethylpyrazine based chalcone derivatives as potential anti-Alzheimer agents. Chem Biol Drug Des 2018;92(5):1859-1866. DOI: 10.1111/cbdd.13355.
25. Amjad MW, Raja MAG. Synthesis and Characterization of Albumin microparticles as carriers for antibiotic Levofloxacin. Int J Pharm Phytopharmacological Res 2018;8(5):80-83. https://eijppr.com/ARTkPUR.
26. Shaheryar ZA, Rehman ZU, Zaman M, Shah S, Khan KUR, Khan SM, Amjad MW, Raja MAG and Zaidi AA. Antibiotic resistance pattern shown by various pathogens, causing infections in neonates. Pak J Pharm Sci 2018;31(6 (Supplementary):2743-2747.
27. Qureshi S, Zaman M, Mahmood A, Shah S, Amjad MW, Shaheryar ZA, Sarfraz RM, Khan SM, Raja MAG. Development and optimization of flurbiprofen loaded microsponges; an in-vitro evaluation. Pak J Pharm Sci 2019;32(4(Supplementary)):1773-1779.
28. Zaman M, Hanif M, Amjad MW, Mahmood A, Shah S, Raja MAG, Rasool S and Sarfraz RM. Development of thiomer based buccal films for the enhancement of bioavailability: An in-vivo analysis. Pak J Pharm Sci 2019;32(2 (Supplementary)):759-764.
29. Amjad MW, Raja MAG. Development and Characterization of Liposome-Enriched Ketoprofen Liposomal Hydrogels. J Pharm Res Int 2019;27(1):1-7. DOI: 10.9734/jpri/2019/v27i130159.
30. Raja MAG, Aljuraisy MN, Alotaibi NM, Amjad MW. Analysis of degree of errors in handwritten medication prescriptions in Rafha, Saudi Arabia. Trop J Pharm Res 2019;18(6):1347-1352. DOI: 10.4314/tjpr.v18i6.28.
31. Mahmood A, Sharif A, Muhammad F, Sarfraz RM, Abrar MA, Qaisar MN, Anwer N, Amjad MW, Zaman M. Development and in vitro evaluation of (β-cyclodextrin-g-methacrylic acid)/Na+-montmorillonite nanocomposite hydrogels for controlled delivery of lovastatin. Int J Nanomedicine 2019;14:5397–5413. doi: 10.2147/IJN.S209662.
32. Hanif M, Shah S, Rasul A, Abbas G, Zaman M, Amjad MW, Raja MAG, Khan HU, Ashfaq M, Iqbal O. Enhancement of Oral Bioavailability of Ibandronate Through Gastroretentive Raft Forming Drug Delivery System: In Vitro and In Vivo Evaluation. Int J Nanomedicine 2020;15:4847-4858. DOI: https://doi.org/10.2147/IJN.S255278.
33. Raja MAG, Al-Shammari SS, Al-Otaibi N, Amjad MW. Public attitude and perception about analgesic and their side effects. J Pharm Res Int 2020;32(3):35-52. DOI: 10.9734/jpri/2020/v32i330412.
34. Iqbal A, Zaman M, Amjad MW, Adnan S, Raja MAG, Rizvi SFH, Mustafa MW, Farooq U, Abbas G, Shah S. Solid Lipid Nanoparticles of Mycophenolate Mofetil: An Attempt to Control the Release of an Immunosuppressant. Int J Nanomedicine 2020;15:5603-5612. https://doi.org/10.2147/IJN.S255636.
35. Raja MAG, Alrawili GH, Al-Otaibi N, Amjad MW. Prevalence of Side Effects, Drug Interaction among Patients Taking Statin in Turaif, Saudi Arabia. J Pharm Res Int 2020;32(3):86-97. DOI: 10.9734/jpri/2020/v32i330417.
36. Zaman M, Qureshi S, Raja MAG, Amjad MW, Sultana K, Rehman AU. Microsponges Carrier for the Safe and Effective Delivery of Mycophenolate Mofetil by Using Ethyl Cellulose-Based and Xanthan Gum-Facilitated Ethyl Cellulose Based Approaches. Bioinspired Biomim Nanobiomaterials 2020;9(4):194-201. https://doi.org/10.1680/jbibn.19.00027.
37. Anwar S, Zaman M, Raja MAG, Mahmood A, Amjad MW. Rosuvastatin, Perindopril and Ezetimibe loaded instant release buccal films: Development and in vitro characterization. J Appl Biomed 2020;18(4):115-125. DOI: 10.32725/jab.2020.015.
38. Alshehri MM, Amjad MW, Mudawi MME. Drugs-Inducing Hepatotoxicity. Asian J Pharm Res Health Care 2020;12(3):148-156. DOI: https://doi.org/10.18311/ajprhc/2020/25518.
39. Zaman M, Hassan R, Razzaq S, Mahmood A, Amjad MW, Raja MAG, Qaisar AA, Majeed A, Hanif M, Tahir RA. Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL. Sci Prog 2020;103(4): 36850420964302. https://doi.org/10.1177/0036850420964302.
40. Amjad MW, Alotaibi NM. Formulation and in vitro Characterization of Donepezil-loaded Chitosan Nanoparticles. J Pharm Res Int 2020;32(10):10-16. DOI: 10.9734/jpri/2020/v32i1030488.
41. Pandey M, Choudhury H, Verma RK, Chawla V, Bhattamisra SK, Gorain B, Raja MAG, Amjad MW. Nanoparticles Based Intranasal Delivery of Drug to Treat Alzheimer's Disease: A Recent Update. CNS Neurol Disord Drug Targets 2020;19(9):648-662. DOI: 10.2174/1871527319999200819095620.
42. Raja MAG, Amjad MW, Alotaibi NM. Development and characterization of Anti Alzheimer drug-loaded chitosan nanoparticles for the enhanced penetration of blood brain barrier. J Pharm Res Int 2021;33(15):33-39. DOI: 10.9734/jpri/2021/v33i1531284.
43. Zaman M, Hassan R, Amjad MW, Khan SM, Raja MAG, Shah SS, Siddique W, Aman W, Abid Z, Butt MH. Formulation of instant disintegrating buccal films without using disintegrant: An in-vitro study. Pak J Pharm Sci 2021;34(6(Supplementary)):2357-2364. DOI: 10.36721/PJPS.2021.34.6.SUP.2357-2364.1.
44. Chughtai FRS, Zaman M, Khan AH, Amjad MW, Aman W, Khan SM, Raja MAG, Raja MNA, Afridi M, Hanif M. Formulation and evaluation of sustained release ocular inserts of betaxolol hydrochloride using arabinoxylan from Plantago ovata. Pak J Pharm Sci 2021;34(3(Supplementary)):1069-1074. DOI: 10.36721/PJPS.2021.34.3.SUP.1069-1074.1.
45. Bukhari SNA, Alotaibi NH, Ahmad W, Alharbi KS, Abdelgawad MA, Al-Sanea MM, Ahmad MM, Amjad MW, Raja MAG, Hussain MA. Evaluation of ligustrazine based synthetic compounds for mechanism based antiproliferative effects. Med Chem 2021;17(9):956-962. DOI: 10.2174/1573406416666200905125038.
46. Amjad MW, Raja MAG. Development and Characterization of Mitoxantrone-Loaded Glutaraldehyde Crosslinked Sodium Alginate Nanoparticles for the Delivery of Anticancer drugs. J Pharm Res Int 2021;33(19A):18-24. DOI: 10.9734/jpri/2021/v33i19A31321.
47. Zaman M, Bajwa RI, Qureshi OS, Rehman AU, Saeed S, Amjad MW, Raja MAG, Hussain MA. Synthesis of Thiol-Modified Hemicellulose, Its Biocompatibility, Studies, and Appraisal as a Sustained Release Carrier of Ticagrelor. Front Pharmacol 2021;12. DOI: 10.3389/fphar.2021.550020.
48. Verma RK, Pandey M, Chawla P, Choudhury H, Mayuren J, Bhattamisra SK, Gorain B, Raja MAG, Amjad MW, Rahman SO. An insight into the role of Artificial Intelligence in the early diagnosis of Alzheimer’s disease. CNS Neurol Disord Drug Targets 2022;21(10):901-912. DOI: 10.2174/1871527320666210512014505.
49. Shahid N, Erum A, Zaman M, Iqbal MO, Riaz R, Tulain R, Hussain T, Amjad MW, Raja MAG, Farooq U, Aman W. Fabrication of thiolated chitosan based biodegradable nanoparticles of ticagrelor and their pharmacokinetics. Polym Polym Compos 2022;30. doi: 10.1177/09673911221108742.
50. Yu FTH, Amjad MW, Mohammed SA, Yu GZ, Chen X, Pacella JJ. Effect of Ultrasound Pulse Length on Sonoreperfusion Therapy. Ultrasound Med Biol 2023;49(1):152-164. doi: 10.1016/j.ultrasmedbio.2022.08.009.
Book Chapters, Editorials, and Review Articles
1. Amin MCIM, Butt AM, Amjad MW, Kesharwani P. Polymeric Micelles for Drug Targeting and Delivery. In book: Nanotechnology-Based Approaches for Targeting and Delivery of Drugs and Genes 1st Edition. Academic Press. 2017;167–202. https://doi.org/10.1016/B978-0-12-809717-5.00006-3.
2. Hussain Z, Thu HE, Amjad MW, Hussain F, Ahmed TA, Khan S. Exploring recent developments to improve antioxidant, anti-inflammatory and antimicrobial efficacy of curcumin: A review of new trends and future perspectives. Mater Sci Eng C 2017;77:1316-1326. DOI: 10.1016/j.msec.2017.03.226.
3. Amjad MW, Kesharwani P, Amin MCIM, Iyer AK. Recent advances in the design, development, and targeting mechanisms of polymeric micelles for delivery of siRNA in cancer therapy. Prog Polym Sci 2017;64:154-181. https://doi.org/10.1016/j.progpolymsci.2016.09.008.
4. Raja MAG, Katas H, Amjad MW. Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA. Asian J Pharm Sci 2019;14(5):497-510. DOI: 10.1016/j.ajps.2018.12.005.
5. Amjad MW. Dendrimers in anticancer targeted drug delivery: accomplishments, challenges and directions for future. Pharm Pharmacol 2021;9(1):4-16. 10.19163/2307-9266-2021-9-1-4-16.
6. Mohammed SA, Amjad MW, Chen X, Acosta MF, Hanrahan D, Unger EC, Meuillet EJ, Pacella JJ. Fibrin targeted phase shift microbubbles for the treatment of microvascular obstruction. J Am College Cardio 2022;79(9_Supplement): 1783. 10.1016/S0735-1097%2822%2902774-7.
7. Amjad MW. Polymeric micelles for drug co-delivery. In book: Polymeric Micelles for Drug Delivery. Woodhead Publishing 2022. 1st Edition - August 1, 2022. Paperback ISBN: 9780323898683. 10.1016/B978-0-323-89868-3.00005-7.
8. Mohammed SA, Amjad MW, Chen X, Acosta MF, Hanrahan D, Unger EC, Meuillet EJ, Pacella JJ. Fibrin-Targeted Phase Shift Microbubbles Outperformed Fibrin-Targeted Microbubbles in Microvascular Obstruction Treatment. The 27th European symposium on Ultrasound Contrast Imaging. January 20-21, 2022.
9. Amjad MW, Mohammed SA, Chen X, Matsunaga TO, Freeman BA, Fazzari M, Pacella JJ.Development and Characterization of Nitro-Fatty Acid Microbubbles (NFABs) for the Treatment of Microvascular Obstruction. The 27th European symposium on Ultrasound Contrast Imaging. January 20-21, 2022.
10. Mohammed SA, Amjad MW, Chen X, Acosta MF, Hanrahan D, Unger EC, Meuillet EJ, Pacella JJ. Abstract 15543: Fibrin-Targeted Phase Shift Microbubbles Outperform Fibrin-Targeted Microbubbles for the Treatment of Microvascular Obstruction. 30 Oct 2022. Circulation 2022;146:A15543.
11. Yu FTH, Amjad MW, Mohammed SA, Yu G, Chen X, Pacella JJ. Abstract 14673: The Effect of Increasing the Ultrasound Pulse Length on Sonoreperfusion Therapy. 30 Oct 2022. Circulation 2022;146:A14673.
