Faculty & Staff

Post Doctoral Fellows

Jonathan Kopechek, PhD

Post-doctoral Fellow, University of Pittsburgh UPMC Heart and Vascular Institute












Peer Reviewed Articles

 

1. Kopechek JA, Abruzzo TM, Wang B, Chrzanowski SM, Smith DAB, Kee PH, Huang S, Collier JH, McPherson DD, Holland CK. Ultrasound-mediated release of hydrophilic and lipophilic agents from echogenic liposomes. J Ultrasound Med 2008;27:1597-1606.

2. Kee PH, Abruzzo TA, Smith DAB, Kopechek JA, Wang B, Huang SL, MacDonald RC, Holland CK, McPherson DD. Synthesis, acoustic stability and pharmacologic activities of Papaverine-loaded echogenic liposomes for ultrasound controlled drug delivery. J Liposome Res 2008;18:263-277.

3. Kopechek JA, Kim H, McPherson DD, Holland, CK. Calibration of the 1-MHz Sonitron ultrasound systems. Ultrasound Med Biol 2010;36:1762-1766.

4. Smith DAB, Vaidya SS, Kopechek JA, Huang SL, Klegerman ME, McPherson DD, Holland CK. Ultrasonically triggered release of recombinant tissue-type plasminogen activator (rt-PA) from echogenic liposomes. Ultrasound Med Biol 2010;36:145-157.

5. Laing ST, Kim H, Kopechek JA, Parikh D, Huang S, Klegerman ME, Holland CK, McPherson DD. Ultrasound-mediated delivery of echogenic immunoliposomes to porcine vascular smooth muscle cells in vivo. J Liposome Res 2010;20:160-167.

6. Herbst SM, Klegerman ME, Kim H, Shelat H, Wassler M, Moody MR, Yang CM, Ge X, Zou Y, Kopechek JA, Clubb FJ, Kraemer DC, Huang S, Holland CK, McPherson DD, Geng YJ. Targeted delivery of stem cells to porcine arterial wall with echogenic liposomes conjugated to antibodies against CD34 and Intercellular Adhesion Molecule-1. Mol Pharm 2010;7:3-11.

7. Kopechek JA, Haworth KJ, Raymond JL, Perrin Jr. SR, Klegerman ME, Huang S, Porter TM, Mast TD, McPherson DD, Holland CK. Acoustic characterization of echogenic liposomes: frequency-dependent attenuation and quantitative backscatter. J Acoust Soc Am 2011;130:3472-3481.

8. Kopechek JA, Zhang P, Burgess MT, Porter TM. Synthesis of phase-shift nanoemulsions with narrow size distributions for acoustic droplet vaporization and bubble-enhanced ultrasound-mediated ablation. J Vis Exp 2012;67:e4308.

9. Haworth KJ, Mast TD, Radhakrishnan K, Burgess MT, Kopechek JA, Huang SL, Klegerman ME, McPherson DD, Holland CK. Passive imaging with pulsed ultrasound insonations. J Acoust Soc Am 2012;132:544-553.

10. Kopechek JA, Haworth KJ, Radhakrishnan K, Huang S, Klegerman ME, McPherson DD, Holland CK. The impact of bubbles on measurement of drug release from echogenic liposomes. Ultrason Sonochem 2013;20:1121-1130.

11. Radhakrishnan K, Bader KB, Haworth KJ, Kopechek JA, Raymond JL, Huang SL, McPherson DD, Holland CK. Relationship between cavitation and loss of echogenicity from ultrasound contrast agents. Phys Med Biol 2013;58:6541-6563.

12. Kopechek JA, Park EJ, Mei CS, McDannold NJ, Porter TM. Accumulation of phase-shift nanoemulsions to enhance MR-guided ultrasound-mediated tumor ablation in vivo. J Healthc Eng 2013;4:109-126.

13. Yohe ST, Kopechek JA, Porter TM, Grinstaff MW. Triggered drug release from 3D superhydrophobic meshes using high-intensity focused ultrasound. Adv Healthc Mater 2013;2:1204-1208.

14. Zhang P, Kopechek JA, Porter TM. The impact of vaporized nanoemulsions on ultrasound-mediated ablation. J Ther Ultrasound 2013;1:2.

15. Kopechek JA, Park EJ, Zhang YZ, Vykhodtseva NI, McDannold NJ, Porter TM. Cavitation-enhanced MR-guided focused ultrasound ablation of rabbit tumors in vivo using phase shift nanoemulsions. Phys Med Biol 2014;59:3465-3481.

16. Parrales MA, Fernandez JM, Perez-Saborid M, Kopechek JA, Porter TM. Acoustic characterization of monodisperse lipid-coated microbubbles: relationship between size and shell viscoelastic properties. J Acoust Soc Am 2014;136:1077-1084.

17. Duncanson WJ, Arriaga LR, Ung L, Kopechek JA, Porter T, Weitz DA. Microfluidic fabrication of perfluorohexane-shelled double emulsions for controlled loading and acoustic-triggered release of hydrophilic agents. Langmuir 2014;30:13765-13770.

18. Kopechek JA, Carson AR, McTiernan CF, Chen X, Hasjim B, Lavery L, Sen M, Grandis JR, Villanueva FS. Ultrasound targeted microbubble destruction-mediated delivery of a transcription factor decoy inhibits STAT3 signaling and tumor growth . Theranostics 2015;5(12):1378-1387.