Faculty & Staff

Faculty & Staff

John J. Pacella, MS, MD

Associate Professor of Medicine, Cardiac Catheterization Laboratory

Faculty Member

Peer Reviewed Articles

1. Goldstein AH, Pacella JJ, Trumble DR, Clark RE. Development of an implantable centrifugal blood pump.  American Society for Artificial Internal Organs 1992;38:M362-M365.

2. Goldstein AH, Pacella JJ, Clark RE.  Predictable reduction of stroke work and ventricular oxygen utilization with an implantable centrifugal blood pump.  Annals of Thoracic Surgery 1994;58:1018-1024.

3. Pacella JJ, Goldstein AH, Magovern GJ, Clark RE. Modified fabrication techniques lead to improved centrifugal blood pump performance.  American Society for Artificial Internal Organs 1994;40:M767-M772.

4. Reddy RC, Goldstein AH, Pacella JJ, Cattivera GR, Clark RE, Magovern GJ. End organ function with prolonged non-pulsatile circulatory support.  American Society for Artificial Internal Organs 1995;41:M547-M551.

5. Clark RE, Goldstein AH, Pacella JJ, Walters RA, Moeller FW, Cattivera GR, Davis SA, Magovern GJ. Progress in development of a small, low-cost implantable centrifugal pump for short-term circulatory assistance.  Annals of Thoracic Surgery 1996;61:12-16.

6. Griffin WP, Savage EB, Clark RE, Pacella JJ, Johnson GA, Magovern JA, Magovern GJ. AB-180 circulatory support system: summary of development and plans for phase I clinical trial.  American Society for Artificial Internal Organs 1998;44:M719-M724.

7. Pacella JJ, Kameneva MV, Lu E, Fischer D, Csikari M, Villanueva FS. A novel hydrodynamic approach for the treatment of coronary artery disease. Eur Heart J 2006;27:2362-2369 (with Editorial Comment).

8. Pacella JJ, Villanueva FS. Effect of coronary stenosis on adjacent bed flow reserve:  assessment of microvascular mechanisms using myocardial contrast echocardiography.  Circulation 2006;114:1940-1947.

9. Villanueva FS, Lu E, Bowry S, Kilic S, Tom E, Wang J, Gretton J, Pacella JJ, Wagner WR.  Myocardial ischemic memory imaging using molecular echocardiography.  Circulation 2007;115:345-352 (with Editorial Comment)

10. Pacella JJ, Kameneva MV, Lavery LL, Bowry S, Schwartz A, Fischer A, Villanueva FS. A novel hydrodynamic method for microvascular flow enhancement.  Biorheology 2009; 46(4):293-308.

11. Pacella JJ, Kameneva MV, Villanueva FS. Drag Reducing Polymers Improve Coronary Flow Reserve through Modulation of Capillary Resistance.  Biorheology 2009;46(5):365-378.

12. Simon MA, Girod JP, Kliner DE, Moguilansky D, Villanueva FS and Pacella JJ.  Detection of elevated right atrial pressure using a simple bedside ultrasound measure. Am Heart J 2010;159:421-427.

13. Pacella JJ, Kameneva MV, Brands J, Lipowsky HH, Vink H, Lavery LL, Villanueva FS.  Modulation of pre-capillary arteriolar pressure with drag reducing polymers: a novel method for enhancing microvascular perfusion.  Microcirculation 2012;19:580-585.

14. Leeman JE, Kim JS, Yu F, Chen X, Kim K, Wang J, Chen X, Villanueva FS, Pacella JJ.  Effect of acoustic conditions on microbubble-mediated microvascular sonothrombolysis.  Ultrasound Med Biol 2012;38:1589-1598.

15. Kim JS, Leeman JE, Kagemann L, Yu FT, Chen X, Pacella JJ, Schuman JS, Villanueva FS, Kim K.  Volumetric quantification of in vitro sonothrombolysis with microbubbles using high resolution optical coherence tomography. J Biomed Opt 2012;17:070502.

16. Brands J, Kliner D, Lipowsky HH, Kameneva MV, Villanueva FS, Pacella JJ. New insights into the microvascular mechanisms of drag reducing polymers: effect on the cell-free layer. PLoS One 2013;8(10):e77252.

17. Chen X, Leeman JL, Wang J, Pacella JJ, Villanueva FS.  New insights into mechanisms of sonothrombolysis using ultra-high-speed imaging. Ultrasound Med Biol 2014:40(1):258-262.

18. Cao H, Yu F, Zhao Y, Scianmarello N, Lee J, Dai W, Jen N, Beebe T, Li R, Ebrahimi R, Chang DS, Mody FV, Pacella J, Tai YC, Hsiai T. Stretchable electrochemical impedance sensors for intravascular detection of lipid-rich lesions in New Zealand White rabbits. Biosens Bioelectron 2014;54:610-616.

19. Webb TN, Ramratnam M, Evans RW, Orchard T, Pacella J,  Erkan E  Atherosclerotic renal artery stenosis as a cause for hypertension in an adolescent patient. Pediatr Nephrol 2014;29:1457-1460.

20. Pacella JJ, Brands J, Schnatz FG, Chen X, Villanueva FS. Treatment of microvascular micro-embolization using microbubbles and long tone-burst-ultrasound: an in vivo study. Ultrasound Med Biol 2015;41:456-564.

21. Chen X, Wang J, Pacella JJ, Villanueva FS. Dynamic behavior of microbubbles during long ultrasound tone-burst excitation: mechanistic insights into ultrasound-microbubble mediated therapeutics using high-speed imaging and cavitation detection. Ultrasound Med Biol 2016;42(2):528-538.

22. Helfield B, Black JJ, Qin B, Pacella JJ, Chen X, Villanueva FS. Fluid viscosity affects the cavitation of lipid encapsulated microbubbles for therapeutic applications. Ultrasound Med Biol 2016;42(3):782-794. EPub 2015 December 07. PMID: 26674676.

23. Black JJ, Yu FTH, Schnatz RG, Chen X, Villanueva FS, Pacella JJ. Effect of thrombus composition and viscosity on sonoreperfusion efficacy in a model of microvascular obstruction. Ultrasound Med Biol 2016;42(9):2220-31. Epub 2016 May 17. PMID: 27207018.

24. Roos ST, Yu FT, Kamp O, Chen X, Villanueva FS, Pacella JJ. Sonoreperfusion therapy kinetics in whole blood using ultrasound, microbubbles and tPA. Ultrasound Med Biol 2016;42(12):3001-3009. Epub 2016 Sep 26. doi: 10.1016/j.ultrasmedbio.2016.08.013. PMID: 27687734.

25. Goyal A, Yu FTH, Tenwalde MG, Chen X, Althouse A, Villanueva FS, Pacella JJ. Inertial cavitation ultrasound with microbubbles improves reperfusion efficacy when combined with tPA in an in vitro model of microvascular obstruction. Ultrasound Med Biol 2017;43(7):1391-1400. Epub 2017 Apr 7. doi: 10.1016/j.ultrasmedbio.2017.02.013.

26. Yu FTH, Chen X, Straub A, Pacella JJ. The role of nitric oxide during sonoreperfusion of microvascular obstruction. Theranostics 2017;7(14):3527-3538. Epub 2017 Aug 18. doi: 10.7150/thno.19422.

27. Yu GZ, Istvanic F, Chen X, Nouraie M, Shiva S, Straub AC, Pacella JJ. Ultrasound-targeted microbubble cavitation with sodium nitrite synergistically enhances nitric oxide production and microvascular perfusion. Ultrasound Med Biol 2020;46(3):667-678. Epub 2019 Dec 3. doi: 10.1016/j.ultrasmedbio.2019.10.012. PMID: 31810801; PMCID: PMC7010556.

28. Istvanic F, Yu G, Yu FTH, Chen X, Pacella JJ. Sonoreperfusion therapy for microvascular obstruction: A step toward clinical translation. Ultrasound Med Biol 2020;46(3):712-720. Epub 2020 Jan 7. doi: 10.1016/j.ultrasmedbio.2019.11.011. PMID: 31924423; PMCID: PMC7010545.

29. Yu GZ, Ramasamy T, Fazzari M, Chen X, Freeman B, Pacella JJ.  Lipid nitroalkene nanoparticles for the focal treatment of ischemia reperfusion, Nanotheranostics 2022;6(2):215–229. doi: 10.7150/ntno.62351. PMID: 34976596; PMCID: PMC8671954.

30. Zeng P, Chen C, Lof J, Stolze E, Li S, Chen X, Pacella JJ, Villanueva FS, Matsunaga T, Everbach EC, Xie F, Porter T. Acoustic detection of retained perfluoropropane droplets within the developing myocardial infarct zone. Ultrasound Med Biol 2022;(accepted for publication).

31. Yu FTH, Amjad MW, Mohammed SA, Yu GZ, Chen X, Pacella JJ. The effect of ultrasound pulse length on sonoreperfusion therapy. Ultrasound Med Biol 2022;(accepted for publication).