Faculty & Staff

Post Doctoral Fellows

Thiruganesh Ramasamy, PhD

Post-Doctoral Fellow, UPMC Heart and Vascular Institute




 

 

 

 

 

 

 

 

Peer Reviewed Articles

 

  1. Visagaperumal D, Venkatesan P, Ramasamy T, Sugumaran M, Bansal GK, Manjeet S, Ravichandran V. Novel Synthesis of Chloromethyl Biphenyl Carboxylic acid. Indian Pharmacist. 2004;3:67-70.
  2. Umadevi SK, Vaijayanthi V, Padmapriya S, Kausalya J, Ramasamy T,Suresh S, Koilraj M, Ravichandiran V. Bioavailability Enhancement- A Review. Research & Reviews in Biosciences. 2008;12:138-159.
  3. Ramasamy T, Umadevi SK, Kona K, Ruttala HB. Nanocochleate- A new drug delivery system. FABAD Journal of Pharmaceutical Science. 2009;34:1-12.
  4. Ramasamy T, Umadevi SK. Solid Lipid Nanoparticle and Nanoparticle Lipid Carrier for Controlled Drug Delivery – A Review of State of Art and Recent Advances. International Journal of Nanoparticles 2010;3:32.
  5. Umadevi SK, Ramasamy T, Suresh S. Preparation and Characterization of Chitosan Tablets of Aceclofenac for Colon Targeted Drug Delivery. Journal of Pharmaceutical Research and Health Care. 2010;2:46.
  6. Umadevi SK, Ramasamy T. Preparation and Characterization of Pectin Pellets of Aceclofenac for Colon Targeted Drug Delivery. Journal of Chemical and Pharmaceutical Research. 2010;2:361.
  7. Umadevi SK, Ramasamy T, Kesavan B. Formulation and Evaluation of Chitosan Microspheres of Aceclofenac for Colon-Targeted Drug Delivery. Biopharmaceutics and Drug Disposition 2010;31:407.
  8. Joo VS, Ramasamy T, Murugan R, Haidar ZS. Nanoncology: A State-of-Art Update. Journal of Bionanoscience 2011;4:13.
  9. Joo VS, Ramasamy T, Haidar ZS. A Novel Self-Assembled Liposome-based Polymeric Hydrogel for Cranio-MaxilloFacial Applications: Preliminary Findings. Polymers. 2011;3:967.
  10. Umadevi SK, Ramasamy T, Suresh S. Preparation and Characterization of Chondroitin sulphate tablets of Aceclofenac for Colon Targeted Drug Delivery. Iranian Journal of Pharmaceutical Research 2011;11:465.
  11. Ramasamy T and Haidar ZS. Formulation, Characterization and Cytocompatibility Evaluation of Novel Core-Shell Solid Lipid Nanoparticles for the Controlled and Tunable Delivery of a Model Protein. Journal of Bionanoscience 2011;5:143.
  12. Ramasamy T, Haidar ZS. Layer-by-Layer Self-Assembly of Polymeric Multi-layers on Solid Lipid Nanoparticles: A Comparative Study via DLS, TEM, AFM and QCM-D. Journal of Bionanoscience 2011;5:155.
  13. Ramasamy T, Haidar ZS. Alginate-Chitosan versus Chitosan-Alginate Multi-layered Assembled Systems: an in situ comparative QCM-D study. Journal of Biomaterials and Tissue Engineering 2012;2:83.
  14. Ramasamy T, Umadevi SK, Ruttala HB, Suresh S. Development of Solid Lipid Nanoparticles Enriched Hydrogels for Topical Delivery of Anti-Fungal Agent. Macromolecular Research 2012;20:682.
  15. Cho HJ, Lee DW, Marasini N, Poudel BK, Kim JH, Ramasamy T, Yoo BK, Choi HG, Yong CS, Kim JO. Optimization of self-microemulsifying drug delivery system for telmisartan using Box–Behnken design and desirability function. Journal of Pharmacy and Pharmacology 2013;65:1440.
  16. Pradhan R, Poudel BK, Ramasamy T, Choi HG, Yong CS, Kim JO. Docetaxel-loaded polylactic acid-co-glycolic acid nanoparticles: formulation, physicochemical characterization and cytotoxicity studies. Journal of Nanoscience and Nanotechnology 2013;13:5948.
  17. Seo YG, Kim DW, Yeo WH, Ramasamy T, Oh YK, Park YJ, Kim JA, Oh DH, Ku SK, Kim JK, Yong CS, Kim JO, Choi HG. Docetaxel-loaded thermosensitive and bioadhesive nanomicelles as a rectal drug delivery system for enhanced chemotherapeutic effect. Pharmaceutical Research 2013;30:1860.
  18. Seo YG, Kim DH, Ramasamy T, Kim JH, Marasini N, Oh YK, Kim DW, Kim JK, Yong CS, Kim JO, Choi HG. Development of docetaxel-loaded solid self-nanoemulsifying drug delivery system (SNEDDS) for enhanced chemotherapeutic effect. International Journal of Pharmaceutics 2013;452:412.
  19. Yeo WH, Ramasamy T, Kim DW, Cho HJ, Kim YI, Cho KH, Yong CS, Kim JO, Choi HG. Docetaxel-loaded thermosensitive liquid suppository: optimization of rheological properties. Archives of Pharmacal Research. 2013;36:1480.
  20. Ramasamy T, Ruttala HB, Shanmugam S, Umadevi SK. Eudragit-coated aceclofenac-loaded pectin microspheres in chronopharmacological treatment of rheumatoid arthritis. Drug Delivery 2013;20:65.
  21. Ramasamy T, Kim JH, Choi HG, Yong CS, Kim JO. Novel Dual Drug loaded Block Ionomer Complex Micelles for Enhanced Therapeutic Efficiency in Chemotherapy. Journal of Biomedical Nanotechnology 2014;10:1304.
  22. Ramasamy T, Tran TH, Choi JY, Kim JH, Choi HG, Yong CS, Kim JO. Chitosan based polyelectrolyte complexes as potential nanoparticulate carriers: Physicochemical and biological characterization. Pharmaceutical Research 2014; 31:1302.
  23. Ramasamy T, Tran TH, Choi JY, Cho HK, Kim JH, Choi HG, Yong CS, Kim JO. Layer-by-layer coated lipid-polymer hybrid nanoparticles designed for use in anticancer drug delivery. Carbohydrate Polymers 2014;102:653.
  24. Tran TH, Ramasamy T, Truong DH, Shin BS, Choi HG, Yong CS, Kim JO. Development of vorinostat-loaded solid lipid nanoparticles to enhance pharmacokinetics and efficacy against multidrug-resistant cancer cells. Pharmaceutical Research 2014;31:1978.
  25. Tran TH, Ramasamy T, Cho HJ, Kim YI, Choi HG, Yong CS, Kim JO. Formulation and optimization of raloxifene-loaded solid lipid nanoparticles to enhance oral bioavailability. Journal of Nanoscience and Nanotechnology 2014; 14:4820.
  26. Tran TH, Ramasamy T, Troung DH, Choi HG, Yong CS, Kim JO. Preparation and characterization of fenofibrate-loaded nanostructured lipid carriers for oral bioavailability enhancement. AAPS PharmSciTech. 2014;15:1509.
  27. Ramasamy T, Kim JH, Choi JY, Tran TH, Choi HG, Yong CS, Kim JO. pH sensitive polyelectrolyte complex micelles for highly effective combination chemotherapy. Journal of Material Chemistry B 2014;2:6324.
  28. Kim DW †, Ramasamy T †, Choi JY, Kim JH, Yong CS, Choi HG, Kim JO. The influence of bile salt on the chemotherapeutic response of decetaxel-loaded thermosensitive nanomicelles. International Journal of Nanomedicine 2014;9: 3815.
  29. Ramasamy T, Haidar ZS, Tran TH, Choi JY, Choi HG, Yong CS, Kim JO. Layer-by-layer assembly of liposomal nanoparticles with PEGylated polyelectrolytes enhances systemic delivery of multiple anticancer drugs. Acta Biomaterialia 2014;10:5116.
  30. Ramasamy T, Kim JO, Yong CS, Umadevi K, Rana D, Jimenez C, Campos J, Ramalingam M, Haidar ZS.  Novel Core–Shell Nanocapsules for the Tunable Delivery of BioactiverhEGF: Formulation, Characterization and Cytocompatibility Studies. Journal of Biomaterials and Tissue Engineering 2015;5:730. 
  31. Choi JY, Ramasamy T, Tran TH, Ku SK, Choi HG, Yong CS, Kim JO. Systemic delivery of axitinib with nanohybrid liposomal nanoparticles inhibits hypoxic tumor growth. Journal of Material Chemistry B 2015;3:408.
  32. Tran TH, Choi JY, Ramasamy T, Truong DH, Nguyen CN, Choi HG, Yong CS, Kim JO. Hyaluronic acid-coated solid lipid nanoparticles for targeted delivery of vorinostat to CD44 overexpressing cancer cells. Carbohydrate Polymer 2015; 114:407.
  33. Pradhan R, Ramasamy T, Choi JY, Kim JH, Poudal BK, Tak JW, Nukolova N, Choi HG, Yong CS, Kim JO. Hyaluronic acid-decorated poly(lactic-co-glycolic acid) nanoparticles for combined delivery of docetaxel and tanespimycin. Carbohydrate Polymer 2015;123:313.
  34. Truong DH, Tran TH, Ramasamy T, Choi JY, Lee HH, Moon C, Choi HG, Yong CS, Kim JO. Development of Solid Self-Emulsifying Formulation for Improving the Oral Bioavailability of Erlotinib. AAPS PharmSciTech 2015;17:466-473.
  35. Truong DH, Tran TH, Ramasamy T, Choi JY, Choi HG, Yong CS, Kim JO. Preparation and Characterization of Solid Dispersion Using a Novel Amphiphilic Copolymer to Enhance Dissolution and Oral Bioavailability of Sorafenib. Powder Technology 2015;283:260.
  36. Tran TH,Ramasamy T, Choi JY, Nguyen HT, Pham TT, Jeong JH, Ku SK, Choi HG, Yong CS, Kim JO. Tumor-targeting, pH-sensitive nanoparticles for docetaxel delivery to drug-resistant cancer cells. International Journal of Nanomedicine 2015;10:5249.
  37. Ramasamy T, Choi JY, Cho HJ, Umadevi SK, Choi HG, Yong CS, Kim JO. Polypeptide-based Micelles for Delivery of Irinotecan: Physicochemical and In vivo Characterization. Pharmaceutical Research 2015;32:1947.
  38. Ramasamy T, Ruttala HB, Choi JY, Tran TH, Ku SK, Choi HG, Yong CS, Kim JO. Engineering of a lipid-polymer nanoarchitectural platform for highly effective combination therapy of doxorubicin and irinotecan. Chemical Communications  2015; 51:5758.
  39. Choi JY, Ramasamy T, Ku SK, Choi HG, Yong CS, Kim JO. PEGylated lipid bilayer-supported mesoporous silica nanoparticle composite for synergistic co-delivery of axitinib and celastrol in multi-targeted cancer therapy. Acta Biomaterialia 2016;39:94-105.
  40. Tran TH, Thapa RK, Nguyen HT, Pham TT, Ramasamy T, Choi HG, Yong CS, Kim JO. Combined phototherapy in anti-cancer treatment: therapeutics design and perspectives. Journal of Pharmaceutical Investigations 2016;46:505-517.
  41. Thapa RK, Choi JY, Gupta B, Ramasamy T, Choi HG, Yong CS, Kim JO. Liquid crystalline nanoparticles encapsulating cisplatin and docetaxel combination for targeted therapy of breast cancer. Biomaterial Sciences. 2016;4:1340-50.
  42. Ramasamy T, Poudel BK, Ruttala H, Choi JY, Hieu TD, Umadevi K, Youn YS, Choi HG, Yong CS, Kim JO. Cationic drug-based self-assembled polyelectrolyte complex micelles: Physicochemical, pharmacokinetic, and anticancer activity analysis. Colloids Surface B Biointerfaces. 2016;146:152-160.
  43. Sundaramoorthy P†, Ramasamy T, Mishra SK, Jeong KY, Yong CS, Kim JO, Kim HM. Engineering of caveolae-specific self-micellizing anticancer lipid nanoparticles to enhance the chemotherapeutic efficacy of oxaliplatin in colorectal cancer cells. Acta Biomaterialia. 2016;42:220-231.
  44. Poudel BK, Gupta B, Ramasamy T, Thapa RK, Youn YS, Choi HG, Yong CS, Kim JO. Development of polymeric irinotecan nanoparticles using a novel lactone preservation strategy. International Journal of Pharmaceutics. 2016;512:75-86.
  45. Ramasamy T, Ruttala HB, Chitrapriya N, Poudal BK, Choi JY, Kim ST, Youn YS, Ku SK, Choi HG, Yong CS, Kim JO. Engineering of cell microenvironment-responsive polypeptide nanovehicle co-encapsulating a synergistic combination of small molecules for effective chemotherapy in solid tumors. Acta Biomaterialia 2017;48:131-143.
  46. Kim J, Ramasamy T, Choi JY, Kim ST, Youn YS, Choi HG, Yong CS, Kim JO. PEGylated polypeptide lipid nanocapsules to enhance the anticancer efficacy of erlotinib in non-small cell lung cancer. Colloids Surface B Biointerfaces. 2017;150:393-401
  47. Ruttala HB, Ramasamy T, Shin BS, Choi HG, Yong CS, Kim JO. Layer-by-layer assembly of hierarchical nanoarchitectures to enhance the systemic performance of nanoparticle albumin-bound paclitaxel. International Journal of Pharmaceutics. 2017;519:11-21
  48. Ruttala HB, Ramasamy T, Poudal BK, Choi Y, Choi JY, Kim J, Ku SK, Choi HG, Yong CS, Kim JO. Molecularly targeted co-delivery of a histone deacetylase inhibitor and paclitaxel by lipid-protein hybrid nanoparticles for synergistic combinational chemotherapy. Oncotarget 2017; 8:14925. doi: 10.18632/oncotarget.14742.
  49. Gupta B, Ramasamy T, Poudel BK, Pathak S, Regmi S, Choi JY, Son Y, Thapa RK, Jeong JH, Kim JR, Choi HG, Yong CS, Kim JO. Development of Bioactive PEGylated Nanostructured Platforms for Sequential Delivery of Doxorubicin and Imatinib to Overcome Drug Resistance in Metastatic Tumors. ACS Applied Materials and Interfaces 2017; 9(11):9280. doi: 10.1021/acsami.6b09163.
  50. Ramasamy T, Ruttala HB, Gupta B, Poudel BK, Choi HG, Yong CS, Kim JO. Smart chemistry-based nanosized drug delivery systems for systemic applications: A comprehensive review. Journal of Controlled Release 2017;258:226-253 .
  51. Ruttala HB†, Ramasamy T†, Gupta B, Choi HG, Yong CS, Kim JO. Multiple polysaccharide-drug complex-loaded liposomes: A unique strategy in drug loading and cancer targeting. Carbohydrate Polymer. 2017;173:57-66.
  52. Ruttala HB, Chitrapriya N, Kaliraj K, Ramasamy T, Shin WH et al. Facile construction of bioreducible crosslinked polypeptide micelles for enhanced cancer combination therapy. Acta Biomaterialia 2017;63:135-149.
  53. Ramasamy T, Sundaramoorthy P, Ruttala HB et al. Polyunsaturated fatty acid-based targeted nanotherapeutics to enhance the therapeutic efficacy of docetaxel. Drug Delivery 2017;24:1262-1272.
  54. Poudel BK, Gupta B, Ramasamy T, Thapa RK et al. PEGylated thermosensitive lipid-coated hollow gold nanoshells for effective combinational chemo-photothermal therapy of pancreatic cancer. Colloids Surface B Biointerfaces 2017;160:73-83.
  55. Ruttala HB, Ramasamy T, Madeshwaran T et al. Emerging potential of stimulus-responsive nanosized anticancer drug delivery systems for systemic applications. Archives of Pharmacal Research 2018;41:111-129.
  56. Choi JY, Gupta B, Ramasamy T, Jeong JH, Jin SG, Choi HG, Yong CS, Kim JO. PEGylated polyaminoacid-capped mesoporous silica nanoparticles for mitochondria-targeted delivery of celastrol in solid tumors. Colloids Surf B Biointerfaces 2018;165:56-66.
  57. Ramasamy T, Ruttala HB, Sundaramoorthy P et al. Multimodal Selenium Nanoshell-capped Au@mSiO2 Nanoplatform for NIR-responsive Chemo-Photothermal Therapy against Metastatic Breast Cancer. NPG Asia Materials 2018;10:197-216.
  58. Poudel BK, Soe ZC, Ruttala HB, Gupta B, Ramasamy T et al. In situ fabrication of mesoporous silica-coated silver-gold hollow nanoshell for remotely controllable chemo-photothermal therapy via phase-change molecule as gatekeepers. International Journal of Pharmaceutics 2018;548:92-103. 
  59. Ramasamy T, Ruttala HB, Kaliraj K, Poudel K, Jin SG, Choi HG, Ku SK, Yong CS, Kim JO. Polypeptide derivative of metformin with the combined advantage of a gene carrier and anticancer activity. ACS Biomaterial Science & Engineering 2019;5:5159-5168.
  60. Ruttala HB, Ramasamy T, Poudel BK, Ruttala RRT, Jin SG, Choi HG, Ku SK, Yong CS, Kim JO.Multi-responsive albumin-lonidamine conjugated hybridized gold nanoparticle as a combined photothermal-chemotherapy for synergistic tumor ablation. Acta Biomaterialia 2020;101:531-543