Intravital Microscopy
In order to better understand capillary hemodynamics and the performance of targeted contrast agents in vivo, our group uses intravital microscopy, which allows real-time observation of microbubble kinetics within the microcirculation of an intact organism. This platform is also used to study microvascular physiology (Dr. John Pacella) using servo null techniques to measure intra-arteriolar and intracapillary pressures.
Above: Photomicrographs of the physiologic effects of drag reducing polymers (DRPs). DRPs are theorized to decrease the cell free layer and decrease plasma skimming.
Source: Center-generated image.
Above: Possible mechanisms of DRP action.
Source: Center-generated image.
